Nicky, Ricky, Dicky and Dawn complain that they are too old to be the spokespersons of Honest Abe's Tire Store, and believe they are under appreciated. They decide to resign from their post, tired of being lumped together as the Harper Quads.
A little while later, the Harpers are replaced by the musical Kramden Quadruplets: Emma, Jules, George and Lyle. Much to their jealousy, the Kramden Quads are musically talented and receive special treatment from Abe, who has big plans for the new quadruplets and is even able to remember their names. The Harper Quads try to convince Abe to let them have their job back. However, Abe believes that their quadruplet charm has worn off since they frequently fight, whereas the Kramden Quads never fight.
The Harper Quads believe that the Kramden Quadruplets aren't really quads since they don't fight. To prove their point, they plan to collect DNA samples from the Kramdens and have it analyzed by Mae's mother. They invite the Kramdens over to the store, only for their plan to be revealed when Emma notices the bag reading DNA sample. The Harpers give Mae the Kramden's DNA samples, and their own DNA samples to be tested.
Abe approaches the Harper Quads and gives them their job back after the Kramden Quadruplets suddenly leave. They are approached by Mae, who reveals that the Kramden Quadruplets are indeed real multiples, however, one of the Harper Quadruplets ain't related to the others. The Harpers are upset that they're not all biologically related, however, Anne and Tom assure them that it's not blood doesn't make family, but love. Mae's mom retests the DNA samples, and it is revealed that one of the samples was contaminated... by their dog, Squishy Paws who's been chewing on everything lately. 
- Lizzy Greene as Dawn Harper
- Casey Simpson as Ricky Harper
- Mace Coronel as Dicky Harper
- Aidan Gallagher as Nicky Harper
- Allison Munn as Anne Harper
- Brian Stepanek as Tom Harper
- Kyla Drew Simmons as Mae Valentine
- Lydia Boland as Molly
- Maddison Hubbard as Emma Kramden
- Savannah Hubbard as Jules Kramden
- Ethan Kent as George Kramden
- Gavin Kent as Lyle Kramden
- Butch Klein as Honest Abe
- In Quadsled, the Harper Quads are still mad at the Kramden Quads for stealing their tire commercial.
- This is one of the highest rated episodes of the show, getting 1.84M viewers and topping Nickelodeon ratings for the night.
- It's unaware how Squishy Paws contaminated the DNA samples.
- Before this Episode aired, Some fans Theroized who was the odd quad: some fans said it was...
- Nicky: For being a brunette instead of a blond.
- Dawn: For being the only girl.
- Ricky: For being only smart person in the group.
- Dicky: For... well... unknown reasons.