Season 2 was announced on November 18, 2014. The season premiered on May 23, 2015 and ended on August 6, 2016. Season 2 arrives characters Madison and Natlee.
As the Harper Quads get themselves into more trouble, they will find themselves out and embark on more crazy adventures.
- Lizzy Greene as Dawn Harper 25/25 episodes
- Casey Simpson as Ricky Harper 25/25 episodes
- Mace Coronel as Dicky Harper 25/25 episodes
- Aidan Gallagher as Nicky Harper 25/25 episodes
- Allison Munn as Anne Harper 25/25 episodes
- Brian Stepanek as Tom Harper 22/25 episodes
- Kyla Drew Simmons as Mae Valentine 11/25 episodes
- Lincoln Melcher as Mack 2/25 episodes
- Siena Agudong as Natlee 5/25 episodes
- Jessica Belkin as Madison 2/25 episodes
- Bob Pflugfleder as Himself 2/25 episodes
Special Guest Cast
- Chris Tallman as Hank
- Ayumi Lizuca as Meredith
- April Audia as Phone
- Monique Gall as Coach Lobo
- Candace Parker as Herself
- Jack Griffo as Himself
- Ciara as Herself
- Daniella Monet as Herself
- Dana Snyder as Himself
- Every Witch Way Cast as Themselves
- Asher Angel as Himself
- Isaak Presley as Derek Moses
- Tony Calvero as JT Steele
- 5/23/15 Wanted: The Sugar Beet Gang (201)
- 5/30/15 No Ifs, ands, or But-ers (203)
- 6/6/15 Urban Legend Outfitters (202)
- 6/13/15 Do-It-All Dawn (204)
- 6/20/15 Unhappy Campers (205)
- 6/27/15 Mall in the Family (207)
- 7/11/15 I Want Candace (209)
- 7/18/15 Sweet Foot Rides (208)
- 7/25/15 The Mighty Quad-Squad (212)
- 11/11/15 Quaddy-Shack (218)
- 11/25/15 Go Hollywood (213-214)
- 1/9/16 Rock 'n' Rules (215)
- 1/16/16 Ballet and the Beasts (217)
- 1/23/16 She Blinded Him with Science (Bob) (211)
- 1/30/16 Harpers for President (206)
- 2/6/16 Doggy Door Afternoon (216)
- 2/13/16 Three Men and a Mae B. (220)
- 2/20/16 Diary of an Angry Quad (225)
- 2/27/16 Quad Court (210)
- 3/5/16 The Quad-Plex (219)
- 7/9/16 Nicky, Ricky, Dicky & Sicky (224)
- 7/16/16 Mission: Un-Quaddable (226)
- 7/23/16 A Brief Case of Popularity (221)
- 7/30/16 New Kid on the Block (223)
- 8/6/16 The Tell-Tale Art (222)
- There were expected to be 20 episodes within the season but the season was later expanded to 25 episodes.
- This season had many hiatus' after a bunch of episodes had aired.
- In this season Natlee seems more aggressive.
- Chris Tallman is from The Thundermans, Ayumi Lizuca has done Bunches of acting performances, April Audia works as the snack machine on Henry Danger and is the producer on NRDD, Monique Gall works on American Horror Story, Candace Parker is a WNBA player, Jack Griffo is on The Thundermans, Ciara is a dancer and singer, Daniella Monet used to be on Victorious and now works on Paradise Run as the game host, Dana Snyder is on The Thundermans, the Every Witch Way Cast is the whole cast of Every Witch Way, Asher Angel is on a Disney show called Andi Mack, Isaak Presley is on a Disney Show called Stuck In the Middle, Tony Calvero is on School of Rock.
- Season 2 is the longest season.
- Season 2 is the lowest viewed season.
- This is the first season without at least one episode with over 2 million views.
- There was five hiatus' during episode airing.